期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 71, 期 2, 页码 325-330出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2009.03.004
关键词
Magnetite nanoparticles; Cellular uptake; Surface charge; Endocytosis
资金
- Special Coordination Funds for Promoting Science and Technology
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
- JSPS Fellows, MEXT
- Grants-in-Aid for Scientific Research [20002006] Funding Source: KAKEN
Internalization of magnetite nanoparticles with diameter of approximately 40 turn into normal and cancer cells was examined by microscopic observation and flow cytometry. Magnetite nanoparticles were synthesized by hydrolysis in an aqueous solution containing ferrous chloride with organic amines as a base. It was demonstrated that the difference in surface charge of magnetite nanoparticles brought about the difference in uptake efficiency. The nanoparticles with positive charge showed higher internalization into human breast cancer cells than the nanoparticles with negative charge, while the degree of internalization of the positively- and negatively-charged nanoparticles into human umbilical vein endothelial cells (HUVEC) was almost the same. (C) 2009 Elsevier B.V. All rights reserved.
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