期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 70, 期 2, 页码 213-217出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2008.12.028
关键词
gamma-Oryzanol; Ca pectinate microparticles; Chitosan; Entrapment efficiency; Response surface methodology
资金
- Korean Government (MOEHRD, Basic Research Promotion Fund) [KRF-2007-313-C00824]
- National Research Foundation of Korea [2007-313-C00824] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Response surface methodology was used to optimize microparticle preparation conditions, including the ratio of pectin:gamma-oryzanol (OZ) (X-1), agitation speed (X-2), and the concentration of emulsifier (X-3), for maximal entrapment efficiency (EE) of OZ-loaded Ca pectinate microparticles. The optimized values of X1, X2, and X3 were found to be 2.72:5.28, 1143.5 rpm, and 2.61%, respectively. Experimental results obtained for the optimum formulation agreed favorably with the predicted results, indicating the usefulness of predicting models for EE. In order to evaluate the effect of chitosan-coating and blending on the release pattern of the entrapped OZ from microparticles, chitosan-coated and blended Ca pectinate microparticles were prepared. Release studies revealed that the chitosan treatments, especially the chitosan-coating, were effective ill Suppressing the release in both simulated gastric fluid (SGF) and intestinal fluid (SIF). (C) 2008 Elsevier B.V. All rights reserved.
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