期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 61, 期 1, 页码 25-29出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2007.06.029
关键词
PLGA; blue dextran; microspheres; drug-loading efficiency
Poly(lactide-co-glycolide), PLGA, microspheres containing blue dextran as a hydrophilic model drug were prepared by a solvent evaporation method from w/o/w emulsions using a micro homogenizer. Effects of surfactant concentration in oil phase, stirring time period and stirring rate in the preparation procedure of primary emulsion (w/o) upon drug-loading efficiency were evaluated. Stirring rate during preparation of primary emulsion and surfactant concentration in oil phase affected drug-loading efficiency and the particle size of primary emulsion. Microspheres having the higher drug-loading efficiency were obtained when size differences between the primary emulsions and the secondary ones were large. That is, when the diameter of the primary emulsion is much smaller than that of the secondary emulsion, PLGA microspheres with high-loading efficiency of blue dextran were obtained. (C) 2007 Elsevier B.V. All rights reserved.
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