期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 67, 期 1, 页码 41-45出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2008.07.012
关键词
Polypyrrole films; Blood compatibility; Platelet adhesion; Fibrinogen adsorption; Electrical conductivity
资金
- MOST/KOSEF [R11-2005-008-000-0]
- Seoul RBD program [10816]
- Brain Korea 21 project
- National High Technology Research and Development Program of China [2006AA03Z445]
- Specialized Research Fund [20050319010]
- Ministry of Education, Science & Technology (MoST), Republic of Korea [2005-03350] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [R11-2005-008-06002-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
A novel O-butyryl chitosan (OBCS)-grafted polypyrrole (PPy) film was described. The immobilization was accomplished by photocrosslinking the OBCS onto PPy films under ultraviolet light irradiation. The surfaces of OBCS-grafted PPy film were characterized by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy and electron spectroscopy for chemical analysis (ESCA). The blood compatibility of the OBCS-grafted PPy film was evaluated by platelet-rich plasma (PRP) contacting experiments and protein adsorption experiments in vitro. These results have demonstrated that the surface with immobilized OBCS shows much less platelet adhesive and fibrinogen adsorption compared to the control surface. The bulk conductivity values of PPy films were measured by a modified four-probe method. The composite films have both good blood compatibility and high electrical conductivity that make them suitable for using as potential biomaterials, such as electrically conducting blood vessel and functionally haemocompatible substrate of biosensor used directly in whole blood. (C) 2008 Elsevier B.V. All rights reserved.
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