期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 67, 期 2, 页码 245-252出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2008.09.002
关键词
PNIPAAm hydrogel; Pendant PDMAEMA; Thermosensitive; pH sensitive; Controlled release
资金
- National Key Basic Research Program of China [2005CB623903]
- Ministry of Education of China [707043]
A series of novel hydrogels based on poly(N-isopropylacrylamide) (PNIPAAm) with pendant poly(N-(2-(dimethylamino) ethyl)- methacrylamide) (PDMAEMA) grafts were designed and synthesized. The influence of the pendant PDMAEMA grafts on the properties of the resulted hydrogels was examined in terms of morphology observed by scanning electron microscopy (SEM), thermal property characterized by differential scanning calorimetry (DSC) and shrinking/swelling kinetics upon external temperature changes. In comparison with the conventional PNIPAAm hydrogels, resulting hydrogels presented favorable pH sensitivity as well as improved thermosensitive properties, including enlarged water containing capability at room temperature and faster shrinking/swelling rate upon heating. In addition, fish DNA, used as a model drug, was loaded into the hydrogels, and the controlled release behavior of the drug-loaded hydrogels at different temperatures (22 and 37 degrees C) was further Studied. (C) 2008 Elsevier B.V. All rights reserved.
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