期刊
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
卷 451, 期 -, 页码 172-180出版社
ELSEVIER
DOI: 10.1016/j.colsurfa.2014.03.035
关键词
Substituted hydroxyapatite; Nanoparticles; Bioceramics; Antibacterial activity; Bioactivity
资金
- Indian Council of Medical Research (ICMR, IRIS) [2010-08660, 5/20/11(Bio)/10-NCD-I]
- Department of Science and Technology, New Delhi, India (DST-TSD) [DST/TSG/NTS/2011/73]
- Department of Science and Technology, New Delhi, India (DST-SERB) [SB/EMEQ-185/2013]
- Council of Scientific and Industrial Research (CSIR) [01(2547)/11/EMR-II]
- University Grants Commission (UGC) [40 -64/2011]
- UGC [F. 30-1/2013 (SA-II)/RA-2012-14-NEW-SC-TAM-3240, F. 30-1/2013(SA-II)/RA-2012-14-NEW-SC-TAM-3228)]
- DST-WOS A [SR/W0S-A/PS26/2012]
Dual ionic substitutions have been anticipated as a tool to improve the mechanical and biological properties of hydroxyapatite (HA). The present work deals with the synthesis of strontium/cerium co-substituted HA nanoparticles (Ca/Sr/Ce-HA) by microwave irradiation method. The properties of pure HA can be tailored to the preferred extent by simultaneous substitution of Sr2+ and Ce3+. To improve the bioactivity of pure HA, strontium (Sr2+) was substituted into it and further co substituted by different concentrations (0.05, 0.075 and 0.1 M) of cerium (Ce3+) to enhance the antibacterial property. All the as-synthesized samples were investigated by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy dispersive X-ray analysis (EDAX), high resolution transmission electron microscopy (HRTEM) and thermo gravimetric analysis (TGA). Moreover the antibacterial activity of the as-synthesized nanoparticles was evaluated against two prokaryotic strains. The in vitro bioactivity of the as prepared Ca/Sr/Ce-HA nanoparticles at optimum concentration (0.1 M) of Ce3+ was examined by soaking it in simulated body fluid (SBF) for various days. The as prepared Ca/Sr/Ce-HA sample at optimum concentration (0.1 M) of Ce3+ can act as a potential candidate for biomedical applications with good antibacterial property and bone bonding ability. (C) 2014 Elsevier B.V. All rights reserved.
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