期刊
COLLOID AND POLYMER SCIENCE
卷 292, 期 7, 页码 1665-1673出版社
SPRINGER
DOI: 10.1007/s00396-014-3227-7
关键词
Ephedrine; Poly(vinyl alcohol); Enantiodifferentiation; Transport properties; Cryogel membranes
资金
- Fundacao para a Ciencia e a Tecnologia (FCT, Portugal)
- Coordenacao para Aperfeicoamento de Pessoal de Nivel Superior (Brazil) [329/13]
- FEDER through COMPETE program
- FCT [PEst-C/QUI/UI0313/2011, PEst-OE/QUI/UI0313/2014]
Equilibrium and transport properties have been investigated of ephedrines, a class of sympathomimetic amines, through cryogel membranes of poly(vinyl alcohol) (PVA). The effect of the PVA (10 to 18 % (w/v)) on the release properties of (1S,2R)-(+)-ephedrine hydrochloride has been discussed on the basis of partition-diffusion and power-law models. The effect of PVA concentration on the swelling degree of PVA-ephedrine matrices have been measured, allowing the estimation of the volume fraction of polymer in the gel. Ephedrine release rate constants, computed by using a first-order kinetics approach, have been modeled by using free-volume and hydrodynamic-scaling models. Differences in the release properties of the ephedrine isomers, (1S,2R)-(+)- and (1R,2S)-(-)-ephedrine as their hydrochlorides, have also been studied at different temperatures. The release kinetic constants and the corresponding activation energies show a marked discrimination between the two ephedrine isomers. This suggests that PVA cryogel membranes possess high potential for enantiomeric differentiation.
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