期刊
COLLOID AND POLYMER SCIENCE
卷 289, 期 10, 页码 1133-1144出版社
SPRINGER
DOI: 10.1007/s00396-011-2437-5
关键词
Chitosan; Heparin; N,N,N-trimethyl chitosan; Polyelectrolyte complexes; CP-MAS C-13 NMR spectroscopy; Heparin delivery
资金
- Fundacao Araucaria
- CNPq, Brazil [309005/2009-4, 481424/2010-5]
Chitosan and N,N,N-trimethyl chitosan (TMC) were treated with heparin (HP) to produce polyelectrolyte complexes (PECs). The structures of PECs were characterized by Fourier transform infrared and CP-MAS C-13 NMR spectroscopies. A thermal stability of TMC/HP complex was evaluated by thermogravimetric analyses, and morphology was investigated by SEM images. The ratio between the carbons bonded to noncharged nitrogen atoms (CI broken vertical bar) and the carbons bonded to positively charged nitrogen atoms (C omega) in TMC was calculated through of the degree quaternization (DQ), being the DQ obtained through H-1 NMR data. Experiments of controlled release of HP were performed in distilled water at pH similar to 7, using methylene blue/heparin system as solute. The release profiles of HP from TMC/HP complex are quite different each other. The value of CI broken vertical bar/C omega ratio was used for explaining such an effect. The CI broken vertical bar/C omega ratio tends to be constantly (similar to 0.69) as high as the pH of medium in which the PEC of TMC/HP was obtained. The change of CI broken vertical bar/C omega ratio on the pH was also considered to explain the improvement of thermal stability of PEC2 with increase of pH. Data show that PEC of TMC/HP formed at pH 8 is a promising material for uses in oral site-specific HP release systems.
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