期刊
COLLOID AND POLYMER SCIENCE
卷 289, 期 4, 页码 447-451出版社
SPRINGER
DOI: 10.1007/s00396-010-2365-9
关键词
Thermo-responsive; pH-responsive; Microgels; Polypeptide; Biodegradable
资金
- National Natural Science Foundation of China [50773081, 50973108, 50733003, 50425309]
- Ministry of Science and Technology of China [2007DFR5020]
- Jilin Science and Technology Bureau [20095003, 20096018]
A novel and facile strategy has been designed to prepare biodegradable microgels with thermo- and pH-responsive property. The microgels were synthesized by the crosslinking of N-isopropylacrylamide with vinyl groups functionalized poly(L-glutamic acid) (PGA). The resultant microgels exhibited pH-dependent phase transition behaviors in aqueous solutions and underwent abrupt lower critical solution temperature decrease when the pH was reduced below the pK (a) of PGA. Dynamic light scattering measurement revealed that the microgels exhibited shrinkage as the temperature increased or the pH decreased.
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