期刊
COLLOID AND POLYMER SCIENCE
卷 290, 期 4, 页码 349-357出版社
SPRINGER
DOI: 10.1007/s00396-011-2558-x
关键词
Fluorine-containing; pH-responsive; Core/shell; Microgel; Controlled drug release
资金
- Key Projects in the National Science and Technology Pillar Program [2008BAC32B03]
- National Natural Science foundation of China [50973027]
A kind of novel fluorine-containing pH-responsive core/shell microgels poly(DMAEMA-co-HFMA)-g-PEG were prepared via surfactant-free emulsion polymerization using water as the solvent. The well-defined chemical structure of the copolymers was characterized by FTIR, H-1-NMR, F-19-NMR, and elemental analysis. The microgel particles were studied by florescence probe technique, dynamic light scattering, and zeta potential measurement; the microgels displayed a significant pH-responsive behavior. Furthermore, the cytotoxicity assay indicated that the copolymer microgels had low toxicity, and 5-FU-loaded microgels offered a certain killing potency against cancer cells. In addition, the drug loading and in vitro drug release demonstrated that 5-FU was successfully incorporated into polymeric microgels, and the drug-loaded microgels showed a marked pH-dependent drug release behavior. This study suggests that the poly(DMAEMA-co-HFMA)-g-PEG microgels play an important role in the release mechanism stimulated by the change in the pH and have potential applications as a controlled drug release carrier.
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