期刊
COLLOID AND POLYMER SCIENCE
卷 289, 期 3, 页码 301-308出版社
SPRINGER
DOI: 10.1007/s00396-010-2349-9
关键词
Hydrogels; Poly(beta-amino ester); Star-shaped copolymer; pH/temperature-sensitive; Biodegradable
资金
- Korean government (MEST) [2010-0027955]
- National Research Foundation of Korea [2010-0029406] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Biodegradable star-shaped copolymers comprised of four-arm poly(ethylene glycol) (4-arm PEG) and poly(beta-amino ester) (PAE) were synthesized by conjugating PAE to 4-arm PEG. The synthesized copolymers were characterized by H-1 and C-13 NMR and gel permeation chromatography. The PAE showed pH/temperature-sensitive properties in an aqueous solution. The copolymer solutions (30 wt.%) showed a gel-to-sol phase transition as a function of temperature in the pH range 7.2-7.8. The gel window covers the physiological conditions (37 A degrees C and pH 7.4) and can be controlled by varying the PAE block length, copolymer solution concentration and PEG molecular weight. After a subcutaneous injection of the copolymer solution into a SD rat, a gel formed rapidly in situ which remained for more than 2 weeks in the body. This copolymer is expected to be a potential candidate for biomedical applications.
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