期刊
COLLOID AND POLYMER SCIENCE
卷 289, 期 5-6, 页码 677-684出版社
SPRINGER
DOI: 10.1007/s00396-010-2314-7
关键词
Hyperbranched copolymer; Reversible addition-fragmentation chain transfer (RAFT) Drug release; pH and temperature sensitivity
资金
- National Natural Science Foundation of China [20604024]
- Natural Science Foundation of Zhejiang Province [Y4100045]
- Qianjiang Talents Project of Zhejiang Province [2010R10023]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars
- State Education Ministry [1001603-C]
- Scientific Research Foundation of Zhejiang Sci-Tech University [0901808-Y]
- Zhejiang Provincal Key Lab of Fiber Materials and Manufacturing Technology
- Zhejiang Sci-Tech University [S2010002]
- Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT) [0654]
Multi-arm star amphiphilic hyperbranched copolymers with poly(2-(dimethylamino) ethyl methacrylate) (PDMAEMA) shell and hyperbranched poly(3-ethyl-3-(hydroxymethyl)oxetane) (HBPO) core were synthesized by reversible addition-fragmentation chain transfer method. The hyperbranched copolymers were further modified by succinic anhydride (SUC) to obtain the novel pH- and thermosensitive hyperbranched copolymer HBPO-star-PDMAEMAs-SUC. The composition and morphology of synthesized copolymers were investigated by H-1 NMR, dynamic light scattering, and transmission electron microscopy. These copolymers exhibited phase transitions in response to pH and temperature. The pH-dependent release properties of the drug-loaded micelles were also investigated using indomethacin (IND) as a model drug. The IND-loaded micelles displayed a rapid drug release at an alkaline pH.
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