期刊
COGNITIVE NEURODYNAMICS
卷 6, 期 6, 页码 537-546出版社
SPRINGER
DOI: 10.1007/s11571-012-9214-0
关键词
Nonlinear analysis; Recurrence quantification analysis (RQA); Approximate entropy; Memory; ERP
资金
- General Clinical Research Center from the National Institutes of Health (NIH)-National Center for Research Resources [M01RR00051]
- NIH [MH64812]
The aim of this study is applying nonlinear methods to assess changes in brain dynamics in a placebo-controlled study of midazolam-induced amnesia. Subjects injected with saline and midazolam during study, performed old/new recognition memory tests with EEG recording. Based on previous studies, as midazolam causes anterograde amnesia, we expected that midazolam would affect the EEG's degree of complexity. Recurrence quantification analysis, and approximate entropy were used in this assessment. These methods compare with other nonlinear techniques such as computation of the correlation dimension, are suitable for non-stationary EEG signals. Our findings suggest that EEG's complexity decreases during memory retrieval. Although this trend is observed in nonlinear curves related to the midazolam condition, the overall complexity were greater than in the saline condition. This result implies that impaired memory function caused by midazolam is associated with greater EEG's complexity compared to normal memory retrieval in saline injection.
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