期刊
COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
卷 12, 期 2, 页码 280-286出版社
SPRINGER
DOI: 10.3758/s13415-011-0078-2
关键词
Acute tryptophan depletion; Affect; Cognitive conflict; Cognitive control; Conflict adaptation; Demand appraisal; Depression; Dysphoria; Effort mobilization; Mood; Serotonin
资金
- Netherlands Organization for Scientific Research
- NWO-MW [904-57-132]
- NWO-VICI [453-06-005]
- chercheur-boursier career award of the Fonds de la Recherche en Sante du Quebec (FRSQ)
Negative affect in healthy populations regulates the appraisal of demanding situations, which tunes subsequent effort mobilization and adjustments in cognitive control. In the present study, we hypothesized that dysphoria in depressed individuals similarly modulates this adaptation, possibly through a neural mechanism involving serotonergic regulation. We tested the effect of dysphoria induced by acute tryptophan depletion (ATD) in remitted depressed patients on conflict adaptation in a Simon task. ATD temporarily lowers the availability of the serotonin precursor L-Tryptophan and is known to increase depressive symptoms in approximately half of remitted depressed participants. We found that depressive symptoms induced by ATD were associated with increased conflict adaptation. Our finding extends recent observations implying an important role of affect in regulating conflict-driven cognitive control.
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