期刊
CNS SPECTRUMS
卷 18, 期 -, 页码 22-33出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S1092852913000734
关键词
Antidepressant treatment; major depressive disorder; monoamine oxidase inhibition
资金
- Mylan Specialty L.P.
The goal of this brief review is to explain the role of monoamine oxidase enzymes in the neurobiology, etiology, and presentation of psychiatric illnesses, primarily major depressive disorder. This article will initially focus on the basic science and function of the monoamine oxidase system and some proposed neuropsychiatric symptoms that may arise if this enzyme system is altered by genetic predisposition. These findings and theories will next be translationally discussed in regard to clinical application pertaining to enzyme inhibition and the treatment of major depressive and other psychiatric disorders.
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