期刊
CLINICS IN SPORTS MEDICINE
卷 28, 期 1, 页码 157-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.csm.2008.08.006
关键词
Interface tissue engineering; Enthesis; Anterior cruciate ligament; Rotator cuff; Scaffold; Co-culture; Tri-culture
资金
- NIAMS NIH HHS [R21 AR056459-02, R01 AR055280-03, R01 AR055280, AR055280-A2, R21 AR056459, R21 AR052402, R21 AR052402-02, AR056459, AR052402] Funding Source: Medline
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R21AR056459, R21AR052402, R01AR055280] Funding Source: NIH RePORTER
Interface tissue engineering is a promising new strategy aimed at the regeneration of tissue interfaces and ultimately enabling the biological fixation of soft tissue grafts used in orthopedic repair and sports medicine. Many ligaments and tendons with direct insertions into subchondral bone exhibit a complex enthesis consisting of several distinct yet continuous regions of soft tissue, noncalcified fibrocartilage, calcified fibrocartilage, and bone. Regeneration of this multi-tissue interface will be critical for functional graft integration and improving long-term clinical outcome. This review highlights current knowledge of the structure-function relationship at the interface, the mechanism of interface regeneration, and the strategic biomimicry implemented in stratified scaffold design for interface tissue engineering and multi-tissue regeneration. Potential challenges and future directions in this emerging field are also discussed. It is anticipated that interface tissue engineering will lead to the design of a new generation of integrative fixation devices for soft tissue repair, and it will be instrumental for the development of integrated musculoskeletal tissue systems with biomimetic complexity and functionality.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据