期刊
CLINICS IN PERINATOLOGY
卷 40, 期 1, 页码 79-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.clp.2012.12.006
关键词
Lactoferrin; Necrotizing enterocolitis; Prophylaxis; Intelectin; Toll-like receptors; Endotoxin binding; Dendritic cells; Th1 cells
资金
- NIH [HD057744]
- Gerber Foundation
Lactoferrin (LF) is a multifunctional protein and a member of the transferrin family. LF and lysozyme in breast milk kill bacteria. In the stomach, pepsin digests and releases a potent peptide antibiotic called lactoferricin from native LF. The antimicrobial characteristics of LF may facilitate a healthy intestinal microbiome. LF is the major whey in human milk; its highest concentration is in colostrum. This fact highlights early feeding of colostrum and also fresh mature milk as a way to prevent necrotizing enterocolitis.
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