期刊
CLINICS IN PERINATOLOGY
卷 39, 期 3, 页码 441-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.clp.2012.06.010
关键词
Respiratory distress syndrome; Bronchopulmonary dysplasia; Lung development; Lung maturation; Lung injury
资金
- NICHD NIH HHS [R01 HD057869, R01 HD072842] Funding Source: Medline
Very preterm infants are commonly exposed to a chronic, often asymptomatic, chorioamnionitis that is diagnosed by histologic evaluation of the placenta only after delivery. The reported effects of these exposures on fetal lungs are inconsistent because exposure to different organisms, durations of exposure, and fetal/maternal responses affect outcomes. In experimental models, chorioamnionitis can both injure and mature the fetal lung and cause immune nodulation. Postnatal care strategies also change how chorioamnionitis relates to clinical outcomes such as bronchopulmonary dysplasia.
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