期刊
CLINICS IN PERINATOLOGY
卷 37, 期 2, 页码 421-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.clp.2009.12.001
关键词
Neonatal sepsis; Bacterial cultures; Blood counts; Acute-phase reactants; Cytokines
Early-onset sepsis remains a major diagnostic problem in neonatal medicine. Definitive diagnosis depends on cultures of blood or other normally sterile body fluids. Abnormal hematological counts, acute-phase reactants, and inflammatory cytokines are neither sensitive nor specific, especially at the onset of illness. Combinations of measurements improve diagnostic test performance, but the optimal selection of analytes has not been determined. The best-established use of these laboratory tests is for retrospective determination that an infant was not infected, based on failure to mount an acute-phase response over the following 24 to 48 hours.
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