期刊
CLINICS IN PERINATOLOGY
卷 35, 期 4, 页码 735-748出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.clp.2008.07.012
关键词
Therapeutic hypothermia; Fetal sheep; Preterm infant; Periventricular leukomalacia
There is strong evidence that prolonged, moderate cerebral hypothermia initiated within a few hours after severe hypoxia-ischemia and continued until resolution of the acute phase of delayed cell death can reduce neuronal loss and improve behavioral recovery in term infants and adults after cardiac arrest. This review examines the evidence that mild to moderate hypothermia is protective after hypoxia-ischemia in models of preterm brain injury and evaluates the potential risks. Induced hypothermia likely has potential to significantly reduce disability. Cautious, systematic trials are essential before hypothermia can be used in these vulnerable infants.
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