期刊
CLINICS IN LIVER DISEASE
卷 14, 期 4, 页码 619-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cld.2010.08.001
关键词
Pediatric cholestasis; Bile salt export pump; Multidrug resistance protein; Genetic diagnosis; Cell polarity
This article describes the uses of immunostaining in the diagnosis of cholestasis To immunostain for bile salt export pump (BSEP) and multidrug resistance protein 3 in severe hepatobiliary disease manifest early in life can rapidly identify whether sequencing of ABCB11 or ABCB4 is likely to yield a genetic diagnosis To immunostain for canalicular ectoenzymes as well as transporters with transmission electron microscopy can suggest whether sequencing of ATP8B1 is likely to yield a genetic diagnosis Demonstrating BSEP expression can direct attention to bile acid synthesis disorders Immunostaining for multidrug resistance-associated protein 2 serves principally as a control for adequacy of processing
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据