期刊
CLINICS IN LIVER DISEASE
卷 14, 期 4, 页码 705-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cld.2010.08.003
关键词
Hepatic progenitor cells; Liver stem cells; Cancer stem cells; Wnt pathway; Notch pathway; Regeneration
Liver progenitor cells are activated in most human liver diseases The dynamics and therefore subpopulations of progenitor cells are however, different in acute versus chronic hepatocytic diseases and in biliary diseases The role of Wnt and Notch signaling pathways in activation and differentiation of human hepatic progenitor cells holds great promise because they can be manipulated by drugs Hepatocytic differentiation requires inhibition of Notch (numb switched on), whereas cholangiocytic differentiation requires Notch activation In this way the patients' own regenerative response could be supported which could eventually even avoid the need for transplantation in several patients
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据