期刊
CLINICS IN LIVER DISEASE
卷 12, 期 4, 页码 825-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cld.2008.07.013
关键词
Liver fibrosis; Cytokines; Angiotensin II; Hepatic stellate cells; Renin-angiotensin system
资金
- Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS)
- Mintisterio de Ciencia y Tecnologia [SAF 2005 06245]
Hepatic fibrosis is the result of a complex interplay between resident hepatic cells, infiltrating inflammatory cells, and a number of locally acting peptides called cytokines. Key mediators include transforming growth factor b1, vasoactive substances, adipokines, inflammatory cytokines and chemokines. Angiotensin 11, the main effector of the renin-angiotensin system, is a true cytokine that plays a major role in liver fibrosis. Angiotensin 11 is locally synthesized in the injured liver and induces profibrogenic actions in hepatic stellate cells. Drugs blocking the renin-angiotensin system are promising antifibrotic agents. There are multiple signal transduction pathways involved in cytokine signaling. Drugs interfering intracellular pathways involved in increased collagen production are potential therapies for liver fibrosis.
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