期刊
CLINICS IN LIVER DISEASE
卷 12, 期 4, 页码 915-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cld.2008.07.001
关键词
Hepatic myofibroblasts; Apoptosis; NF-kappa B; Fibrosis; Extracellular matrix; Neovascularisation
资金
- UK Medical Research Council
- British Liver Trust
- Wellcome Trust
The concept that liver fibrosis is a dynamic process with potential for regression as well as progression has emerged in parallel with clinical evidence for remodeling of fibrotic extracellular matrix in patients who can be effectively treated for their underlying cause of liver disease. This article reviews recent discoveries relating to the cellular and molecular mechanisms that regulate fibrosis regression, with emphasis on studies that have used experimental in vivo models of liver disease. Apoptosis of hepatic myofibroblasts is discussed. The functions played by transcription factors, receptor-ligand interactions, and cell-matrix interactions as regulators of the lifespan of hepatic myofibroblasts are considered, as are the therapeutic opportunities for modulating these functions. Growth factors, proteolytic enzymes, and their inhibitors are discussed in detail.
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