期刊
CLINICS IN LABORATORY MEDICINE
卷 34, 期 4, 页码 771-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cll.2014.08.008
关键词
Proton pump inhibitors; Gastric acid suppression; Hypergastrinemia; Human microbiome; Barrett's esophagus; Helicobacter pylori; Small bowel bacterial overgrowth; Clostridium difficile infection
资金
- National Institutes of Health [T32 DK083256, UL1 RR024156]
- National Center for Advancing Translational Sciences, NIH [UL1 TR000040]
- American Gastroenterological Association Research Scholar Award
- Columbia University's Irving Scholar Award
- NIH [U54 CA 163004]
Potent gastric acid suppression using proton pump inhibitors (PPIs) is common in clinical practice but may have important effects on human health that are mediated through changes in the gastrointestinal microbiome. In the esophagus, PPIs change the normal bacterial milieu to decrease distal esophageal exposure to inflammatory gram-negative bacteria. In the stomach, PPIs alter the abundance and location of gastric Helicobacter pylori and other bacteria. In the small bowel, PPIs cause polymicrobial small bowel bacterial overgrowth and have been associated with the diagnosis of celiac disease. In the colon, PPIs associate with incident but not recurrent Clostridium difficile infection.
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