期刊
CLINICS IN CHEST MEDICINE
卷 30, 期 4, 页码 811-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ccm.2009.08.014
关键词
Tuberculosis; Vaccine; Prophylaxis; Adjuvant; Trial; BCG; HIV; Latency; Infection
The only currently licensed tuberculosis (TB) vaccine, bacille Calmette Guerin, confers incomplete protection against tuberculosis, and is not safe in infants infected with the human immunodeficiency virus. A new, safe vaccine regimen, which better protects against lung disease, is urgently needed to control TB in high-burden countries. Multiple candidate vaccines have shown promise in preclinical studies, and are now entering phase 1 to 2B clinical trials. This article discusses progress in the field and issues surrounding safety, reactogenicity, immunogenicity, and efficacy testing of new TB vaccines.
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