期刊
CLINICS IN CHEST MEDICINE
卷 29, 期 4, 页码 689-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ccm.2008.06.005
关键词
Sepsis; Resuscitation; Early goal-directed therapy; Fluids; Vasopressor; Inotropes
资金
- National Institute of Allergy and infectious Disease
- Hutchinson Technologies
Key links in the chain of survival for the management of severe sepsis and septic shock are early identification and comprehensive resuscitation of high-risk patients. Multiple studies have shown that the first 6 hours of early sepsis management are especially important from a diagnostic, pathogenic, and therapeutic perspective, and that steps taken during this period can have a significant impact on outcome. The recognition of this critical time period and the robust outcome benefit realized in previous studies provides the rationale for adopting early resuscitation as a distinct intervention. Sepsis joins trauma, stroke, and acute myocardial infarction in having golden hours, representing a critical opportunity early on in the course of disease for actions that offer the most benefit.
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