4.7 Review

Cellular and molecular effects of sirtuins in health and disease

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A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

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A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

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SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation

Alejandro Vaquero et al.

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Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity

Eun-Joo Kim et al.

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SIRT1 controls endothelial angiogenic functions during vascular growth

Michael Potente et al.

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SIRT1 deacetylates and positively regulates the nuclear receptor LXR

Xiaoling Li et al.

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SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase

Ilwola Mattagajasingh et al.

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Interphase Nucleo-Cytoplasmic Shuttling and Localization of SIRT2 during Mitosis

Brian J. North et al.

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Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1

Joseph T. Rodgers et al.

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SIRT1 regulates the function of the nijmegen breakage syndrome protein

Zhigang Yuan et al.

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Sirt1 regulates aging and resistance to oxidative stress in the heart

Ralph R. Alcendor et al.

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Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1α

Zachary Gerhart-Hines et al.

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Nucleocytoplasmic shuttling of the NAD+-dependent histone deacrtylase SIRT1

Masaya Tanno et al.

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SIRT1 inhibits transforming growth factor β-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation

Shinji Kume et al.

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Resveratrol improves health and survival of mice on a high-calorie diet

Joseph A. Baur et al.

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Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases

William C. Hallows et al.

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Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2

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Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin-induced diabetic rats

Hui-Chen Su et al.

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Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

R Mostoslavsky et al.

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SIRT1 protects against microglia-dependent amyloid-β toxicity through inhibiting NF-κB signaling

J Chen et al.

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SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1α

S Nemoto et al.

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Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

JT Rodgers et al.

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The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells

JR Revollo et al.

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FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2SIRT1

A van der Horst et al.

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Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

H Daitoku et al.

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Sir2 mediates longevity in the fly through a pathway related to calorie restriction

B Rogina et al.

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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

F Picard et al.

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Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase

F Yeung et al.

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Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

HL Cheng et al.

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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

KT Howitz et al.

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Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state

M Fulco et al.

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The mammalian SIR2 alpha protein has a role in embryogenesis and gametogenesis

MW McBurney et al.

MOLECULAR AND CELLULAR BIOLOGY (2003)

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Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast Sir2 and human SIRT1

KJ Bitterman et al.

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Negative control of p53 by Sir2α promotes cell survival under stress

JY Luo et al.

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hSIR2SIRT1 functions as an NAD-dependent p53 deacetylase

H Vaziri et al.

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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

HA Tissenbaum et al.

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Silent information regulator 2 family of NAD-dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose

KG Tanner et al.

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Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

RA Frye

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