期刊
CLINICAL SCIENCE
卷 120, 期 5-6, 页码 219-229出版社
PORTLAND PRESS LTD
DOI: 10.1042/CS20100462
关键词
cardiovascular disease; cardioprotection; drug therapy; hydrogen sulfide (H2S); nitric oxide (NO)
资金
- National Institutes of Health [NIH 5R01 HL092141-02, NIH 1R01 HL093579 01A1]
- Carlye Fraser Heart Center (CFHC) of Emory University Hospital Midtown
- Ikaria Inc.
H2S (hydrogen sulfide), viewed with dread for more than 300 years, is rapidly becoming a ubiquitously present and physiologically relevant signalling molecule. Knowledge of the production and metabolism of H2S has spurred interest in delineating its functions both in physiology and pathophysiology of disease. Although its role in blood pressure regulation and interaction with NO is controversial, H2S, through its anti-apoptotic, anti-inflammatory and antioxidant effects, has demonstrated significant cardioprotection. As a result, a number of sulfide-donor drugs, including garlic-derived polysulfides, are currently being designed and investigated for the treatment of cardiovascular conditions, specifically myocardial ischaemic disease. However, huge gaps remain in our knowledge about this gasotransmitter. Only by additional studies will we understand more about the role of this intriguing molecule in the treatment of cardiovascular disease.
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