期刊
CLINICAL SCIENCE
卷 118, 期 1-2, 页码 61-69出版社
PORTLAND PRESS LTD
DOI: 10.1042/CS20090063
关键词
blood pressure; fat emulsion; fatty acid; hypertension; insulin; sympathetic nerve activity
资金
- American College of Sports Medicine Foundation Research Grant
- National Institutes of Health [T32 AG00048, M01 RR10732]
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR010732] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [T32AG000048] Funding Source: NIH RePORTER
Previous studies have shown that acute increases in plasma NEFAs (non-esterified fatty acids) raise SVR (systemic vascular resistance) and BP (blood pressure). However, these studies have failed to distinguish between CNS (central nervous system) mechanisms that raise sympathetic activity and paracrine mechanisms that increase SVR directly, independent of CNS involvement. The aim of the present study was to directly determine whether the sympathetic nervous system contributes to the pressor response to NEFAs. On 2 days separated by at least 2 weeks, 17 lean healthy volunteers (ten male/seven female; age, 22+/-1 years; body mass index, 23+/-1 kg/m(2); values are means+/-S.E.M.) received a 4-h intravenous infusion of 20% Intralipid(R) or placebo (in a single-blind randomized balanced order). MSNA (muscle sympathetic nerve activity), HR (heart rate), BP (oscillometric brachial measurement) and (Q) over dot (cardiac output; acetylene rebreathing) were measured before and throughout infusion. The change in HR (+8.2+/-1.0 and +2.4+/-1.2 beats/min), systolic BP (+14.0+/-1.6 and +3.2+/-2.5 mmHg) and diastolic BP (+8.2+/-1.0 and -0.1+/-1.7 mmHg) were significantly greater after the 4-h infusion of Intralipid(R) compared with placebo (P < 0.001). The change in BP with Intralipid(R) resulted from an increase in SVR ((Q) over dot/mean arterial pressure; P < 0.001) compared with baseline, without a change in (Q) over dot. MSNA burst frequency increased during Intralipid(R) infusion compared with baseline (+4.9+/-1.3 bursts/min; P < 0.05), and total MSNA (frequency x amplitude) was augmented 65% (P < 0.001), with no change during placebo infusion. Lipid infusion increased insulin, aldosterone and F-2-isoprostane, but not leptin, concentrations. On the basis of the concomitant increase in BR MSNA and SVR, we conclude that central sympathetic activation contributes to the pressor response to NEFAs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据