期刊
CLINICAL SCIENCE
卷 116, 期 5-6, 页码 507-512出版社
PORTLAND PRESS LTD
DOI: 10.1042/CS20080382
关键词
cardiovascular disease; insulin-like growth factor-I (IGF-I); insulin-like growth factor-binding protein-3 (IGFBP-3); insulin resistance; metabolic syndrome; Third National Health and Nutrition Examination Survey (NHANES III)
资金
- European Foundation for the Study of Diabetes/Lilly Research
- Swedish Heart and Lung Foundation
- Karolinska Insitutet (KID Award)
- Swedish Research Council [15352]
- Swedish Diabetes Association
- National Institutes of Health [R01 HL73211]
- Erling-Persson Foundation
- Stockholm County Council
- Swedish Council for Working Life and Social Research
Recent reports suggest that IGF (insulin-like growth factor)-I and IGFBP-3 (IGF-binding protein-3) have independent and opposing mechanistic effects on insulin. The aim of the present study was to assess the relationship between the IGF-I/IGFBP-3 ratio and the metabolic syndrome. We examined 3281 subjects (1463 men and 1818 women, aged 20-49 years), otherwise healthy adults, who participated in NHANES III (Third National Health and Nutrition Examination Survey), which has released measurements of IGF-I and IGFBP-3. Insulin resistance was estimated using the computer HOMA2 (homoeostatic model assessment 2) model. The updated ATP-III (Adult Treatment Panel III) definition of the metabolic syndrome was used. We applied adjusted logistic and linear regression models. After adjusting for age and race, men and women in the lowest quartile of the IGF-I/IGFBP-3 ratio were 3-fold more likely to meet the ATP-III definition of the metabolic syndrome and twice as likely to be insulin-resistant. Mean values of the IGF-I/IGFBP-3 ratio decreased significantly as the number of metabolic syndrome components increased (P < 0.0001, as determined by ANOVA). The area under the ROC (receiver operating characteristic) curve for detecting insulin resistance using the IGF-I/IGFBP-3 ratio was 0.760, significantly improving upon either protein alone (P=0.01). In conclusion, the IGF-I/IGFBP-3 ratio is significantly associated with the metabolic syndrome. Calculating the ratio of these two proteins may provide insight into the metabolic syndrome clustering phenomenon.
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