期刊
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
卷 36, 期 1, 页码 30-39出版社
HUMANA PRESS INC
DOI: 10.1007/s12016-008-8087-9
关键词
Autoimmunity; Autoimmune disease; Bile ducts; Cholestasis; Liver; Immunity; Tolerance
Infectious agents have been postulated to play a pathogenic role in the loss of immunological tolerance and the induction of primary biliary cirrhosis, an immune-mediated cholestatic liver disease characterized by progressive destruction of the small intrahepatic bile ducts and subsequent cirrhosis and liver failure. This review discusses emerging issues implicating infectious agents such as Escherichia coli, mycobacteria, chlamydia, helicobacter species, lactobacilli, Novosphingobium aromaticivorans, and betaretroviruses in the pathogenesis of primary biliary cirrhosis. We also review the immunopathological mechanisms responsible for the induction of the disease with special emphasis on the role of molecular mimicry and microbial/self immunological cross-reactivity.
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