期刊
CLINICAL PHARMACOLOGY & THERAPEUTICS
卷 96, 期 4, 页码 470-476出版社
WILEY
DOI: 10.1038/clpt.2014.121
关键词
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资金
- European Union [602108]
- MRC [MC_U137686853, MC_qA137929, MR/L006758/1] Funding Source: UKRI
- Medical Research Council [MC_U137686853, MC_qA137929, MR/L006758/1] Funding Source: researchfish
- National Institute for Health Research [CL-2006-06-010, NF-SI-0512-10064] Funding Source: researchfish
- Versus Arthritis [18474] Funding Source: researchfish
Statins are widely used lipid-lowering drugs that are effective in reducing cardiovascular disease risk. Although they are generally well tolerated, they can cause muscle toxicity, which can lead to severe rhabdomyolysis. Research in this area has been hampered to some extent by the lack of standardized nomenclature and phenotypic definitions. We have used numerical and descriptive classifications and developed an algorithm to define statin-related myotoxicity phenotypes, including myalgia, myopathy, rhabdomyolysis, and necrotizing autoimmune myopathy.
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