期刊
CLINICAL PHARMACOLOGY & THERAPEUTICS
卷 94, 期 5, 页码 574-581出版社
WILEY
DOI: 10.1038/clpt.2013.157
关键词
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资金
- E-Institutes of Shanghai Municipal Education Commission [E 03008, 085ZY1205]
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning [2011-50]
The recognition of the gut microbial-mammalian metabolic axis and its implications in human metabolic disease opens a new window to understanding the contribution of the gut microbiome to drug metabolism and drug-induced toxicity. The integrative omics approaches, including pharmacometabonomics and metagenomics, have demonstrated great promise for characterizing xenobiotic interventions that are associated with wide variation in efficacy or toxicity in humans, as well as for predicting individual response and susceptibility to toxicity.
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