期刊
CLINICAL PHARMACOLOGY & THERAPEUTICS
卷 94, 期 4, 页码 445-448出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/clpt.2013.146
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资金
- Brigham and Women's Hospital
Neprilysin inhibitors augment the natriuretic peptide system by preventing the breakdown of atrial natriuretic peptide and B-type natriuretic peptide. LCZ696, an angiotensin receptor neprilysin inhibitor composed of a neprilysin inhibitor prodrug and the angiotensin receptor antagonist valsartan, has proven effective in hypertension, has shown promise in a pilot trial of heart failure with preserved ejection fraction, and is being tested in a large outcomes trial of heart failure with reduced ejection fraction. A preserved ejection fraction outcomes trial is beginning.
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