期刊
CLINICAL PHARMACOLOGY & THERAPEUTICS
卷 94, 期 6, 页码 636-639出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/clpt.2013.175
关键词
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资金
- US Food and Drug Administration's Medical Countermeasures initiative
- National Institutes of Health [GM61390, T32 GM007175]
- National Institute of General Medical Sciences [U01 GM092655]
The neuroprotective function of the blood brain barrier (BBB) presents a major challenge for drug delivery to the central nervous system (CNS). Critical to this function, BBB membrane transporters include the ATP-binding cassette (ABC) transporters, which limit drug penetration across the BBB, and the less-well-studied solute carrier (SLC) transporters. In this work, expression profiling of 359 SLC transporters, comparative expression analysis with kidney and liver, and immunoassays in brain microvessels (BMVs) identified previously unknown transporters at the human BBB.
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