期刊
CLINICAL PHARMACOLOGY & THERAPEUTICS
卷 92, 期 5, 页码 553-556出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/clpt.2012.126
关键词
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The Second International Transporter Consortium (ITC) Workshop was held with the purpose of expanding on previous white-paper recommendations, discussing recent regulatory draft guidance documents on transporter-drug interactions, and highlighting transporter-related challenges in drug development. Specific goals were to discuss additional clinically relevant transporters (MATEs, MRP2, BSEP) and best-practice methodologies and to re-evaluate ITC decision trees based on actual case studies. The outcome of the workshop will be a series of white papers targeted for publication in 2013.
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