期刊
CLINICAL PHARMACOLOGY & THERAPEUTICS
卷 92, 期 5, 页码 546-548出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/clpt.2012.145
关键词
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Therapy with two or more drugs is more the rule than the exception, particularly in aging societies. Drug-drug interactions are frequently undesirable and may lead to increased toxicity and mortality. Inhibition of transporters is one major mechanism underlying drug-drug interactions. The myriad of potential drug combinations makes it very challenging to predict drug-drug interactions. This Commentary discusses potential advantages and limitations of endogenous compounds for predicting transporter-mediated drug-drug interactions.
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