期刊
CLINICAL PHARMACOLOGY & THERAPEUTICS
卷 90, 期 6, 页码 774-776出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/clpt.2011.222
关键词
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Clopidogrel is an important antiplatelet agent, but a considerable variability in the biological effect of the drug has been observed. Additionally, patients with insufficient platelet reactivity inhibition following a loading dose (LD) of clopidogrel have a poor outcome. The mechanisms of variability are dependent on genetic polymorphisms of enzymes involved in clopidogrel metabolism. Paraoxonase 1 has been identified as the main determinant of the biological and clinical efficacy of clopidogrel. This finding could enable the use of pharmacogenomics to tailor antiplatelet agents.
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