期刊
CLINICAL PHARMACOLOGY & THERAPEUTICS
卷 88, 期 5, 页码 704-707出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/clpt.2010.173
关键词
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资金
- Division of Microbiology and Infectious Diseases of the National Institute of Allergy and Infectious Diseases [N01 AI-30025, N01 AI-65306, N01 AI-15113, N01 AI-62554]
Dose-finding studies of influenza antiviral drugs are challenging because it is difficult to enroll subjects in pediatric interventional studies and also because of the lack of concentration (or toxicity)-response relationships, the short duration of antiviral therapy, and the continually developing metabolic profiles of infants and young children. The evaluation of influenza antiviral agents in premature infants adds even more complexity. Recent advances in exposure-targeted study designs and modeling and simulations have aided in addressing some of these challenges.
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