期刊
ANGIOLOGY
卷 67, 期 6, 页码 571-581出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0003319715604762
关键词
epidemiology; sex differences; coronary angiography; major adverse cardiovascular events
资金
- Netherlands Heart Foundation [2013T084]
- Queen of Hearts: Improving diagnosis of CVD in women
- Royal Netherlands Academy of Arts and Sciences
- National University Singapore Startup grant
- Singapore National Medical Research Council Centre Grant
- ATTRaCT, grant BMRC [SPF 2014/003]
- UCL Hospitals NIHR Biomedical Research Centre
- Dutch Heart Foundation [2014T001]
Background: Coronary artery disease affects both men and women. In this study, we examine sex-specific differences in occurrence of major adverse cardiovascular events (MACEs) after coronary angiography. Methods: We analyzed data from the coronary angiography cohort Utrecht Coronary Biobank (n = 1283 men, 480 women). Using Kaplan-Meier and multivariable Cox-regression, we tested for sex differences in MACE occurrence. Additionally, we compared mortality with an age- and sex-matched control group from the general Dutch population. Results: During a median follow-up of 2.1 years (interquartile range 1.6-2.8), MACEs occurred in 265 men and 103 women (20.7% vs 21.3%, P = .744). Women with myocardial infarction (MI) had significantly more MACE during follow-up than men (hazard ratio [HR] 1.66 for female sex, 95% confidence interval [CI] 1.10-2.50, P = .015), which was also the case for women who had multivessel disease (HR 1.41, 95% CI 1.03-1.94, P = .031). During follow-up, mortality in women presenting with MI was higher than mortality of women in the general population; men with MI did not show this disadvantage. Conclusion: MACEs occurred more often in women than in men who presented with MI or who had angiographic multivessel disease upon coronary angiography. Clinical trial registration: Clinicaltrials.gov identifier: NCT02304744. URL: https://clinicaltrials.gov/ct2/show/NCT02304744.
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