期刊
CLINICAL PHARMACOLOGY & THERAPEUTICS
卷 86, 期 5, 页码 507-510出版社
WILEY
DOI: 10.1038/clpt.2009.103
关键词
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资金
- Lucile Packard Foundation for Children's Health, National Library of Medicine [K22 LM008261, T15 LM007033]
- National Institute of General Medical Sciences [R01 GM079719]
- Howard Hughes Medical Institute
- Pharmaceutical Research and Manufacturers of America Foundation
Drug repositioning refers to the discovery of alternative uses for drugs-uses that are different from that for which the drugs were originally intended. One challenge in this effort lies in choosing the indication for which a drug of interest could be prospectively tested. We systematically evaluated a drug treatment-based view of diseases in order to address this challenge. Suggestions for novel drug uses were generated using a guilt by association approach. When compared with a control group of drug uses, the suggested novel drug uses generated by this approach were significantly enriched with respect to previous and ongoing clinical trials.
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