期刊
CLINICAL PHARMACOLOGY & THERAPEUTICS
卷 85, 期 1, 页码 25-30出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/clpt.2008.103
关键词
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Genetics-based personalized approaches to pain management have received a setback because of the nonreproducibility of functional genetic associations such as the pain-modulatory effect(1,2) of the catechol-O-methyl transferase (COMT) gene 472G > A single-nucleotide polymorphism. (3,4)Given that many of the pain-relevant genetic variants are common (allelic frequencies of 10-50%), we hypothesized that a major reason for difficulties in reproducing demonstrations of genetic influences on pain is the concomitant presence in a single individual of several functional genetic polymorphisms that act as confounders.
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