期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 50, 页码 15046-15050出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201507955
关键词
alcohols; amine alkylation; base metals; hydrogen-transfer catalysis; cobalt
资金
- Deutsche Forschungsgemeinschaft (DFG) [KE756/23-2]
The implementation of inexpensive, Earth-abundant metals in typical noble-metal-mediated chemistry is a major goal in homogeneous catalysis. A sustainable or green reaction that has received a lot of attention in recent years and is preferentially catalyzed by Ir or Ru complexes is the alkylation of amines by alcohols. It is based on the borrowing hydrogen or hydrogen autotransfer concept. Herein, we report on the Co-catalyzed alkylation of aromatic amines by alcohols. The reaction proceeds under mild conditions, and selectively generates monoalkylated amines. The observed selectivity allows the synthesis of unsymmetrically substituted diamines. A novel Co complex stabilized by a PN5P ligand catalyzes the reactions most efficiently.
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