期刊
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
卷 466, 期 6, 页码 1503-1509出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1007/s11999-008-0196-5
关键词
-
资金
- NINDS NIH HHS [K12 NS001690, K12 NS01690] Funding Source: Medline
We treated a patient with multiple congenital joint dislocations and facial dysmorphisms consistent with Larsen syndrome. Sequencing of the FLNB gene resulted in identification of a novel, de novo 508G > C point mutation resulting in substitution of proline for a highly conserved alanine (A170P). This mutation has not been described previously but is likely causative because this alanine is highly conserved and is located in the calponin homology domain where other mutations have been described. We also report the successful use of a minimally invasive technique in achieving initial correction of bilateral congenital knee dislocations in this patient. The technique consists of serial manipulations and castings followed by an open quadriceps tenotomy. Longer followup is needed to ensure maintenance of correction and to avoid the need for more extensive surgery, which has been the traditional treatment for congenital knee dislocation associated with Larsen syndrome.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据