期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 40, 页码 11647-11651出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201501461
关键词
dendrimers; fluorine; gene delivery; self-assembly
资金
- NSFC [21322405, 21474030]
- Shanghai Municipal Science and Technology Commission [13A1401500, 148014518]
An ideal vector in gene therapy should exhibit high serum stability, excellent biocompatibility, a desired transfection efficacy and permeability into targeted tissues. Here, we describe a class of low-molecular-weight fluorodendrimers for efficient gene delivery. These materials self-assemble into uniform nanospheres and allow for efficient transfection at low charge ratios and very low DNA doses with minimal cytotoxicity. Our results demonstrate that these vectors combine the features of synthetic gene vectors such as liposomes and cationic polymers and present promising potential for clinical gene therapy.
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