期刊
CLINICAL ONCOLOGY
卷 23, 期 4, 页码 261-267出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.clon.2011.01.160
关键词
Iodine; papillary cancer; radiation; subtypes; thyroid cancer
类别
资金
- Grants-in-Aid for Scientific Research [22590344] Funding Source: KAKEN
The Chernobyl accident was followed by a large increase in the incidence of thyroid carcinoma in the areas exposed to high levels of fallout. The Chernobyl Tumor Bank was set up in 1998 to make tumours available for study internationally, and a pathology panel reviewed all the tumours and established an agreed diagnosis. The thyroid tumours that were discovered after the Chernobyl nuclear accident were virtually all (95%) of the papillary carcinoma type. Rare examples of other tumour types were identified. Within the papillary group, several subtypes were noted, including classical or usual type, follicular variant, solid variant and mixed patterns Diffuse sclerosis variant, cribriform/morular type and Warthin-like variant were rare. No tall cell or columnar cell variants were identified. The tumours examined by the Pathology Panel of the Chernobyl Tumor Bank constitute a large representative sample (estimated at about 50%) of the tumours that developed in this population. This overview describes the method adopted by the panel and the different diagnostic categories adopted; illustrates the pathology of these neoplasms; compares the pathological characteristics of the early lesions with those identified after long latency periods and the institution of screening programmes and outlines the possible associated causes for the various morphological patterns seen. (C) 2011 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
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