期刊
CLINICAL ONCOLOGY
卷 21, 期 6, 页码 464-472出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.clon.2009.04.007
关键词
Advanced NSCLC; dipeptidyl peptidases; docetaxel; talabostat; lung cancer; PT100
类别
Aims: Currently available therapies do improve survival in advanced stage non-small cell lung cancer (NSCLC), but only to a limited degree. Talabostat mesilate (PT-100) is an orally available amino boronic dipeptide that specifically inhibits dipeptidyl peptidases (including fibroblast activation protein) and enhances an immune response. The aim of this study was to determine the efficacy and safety of talabostat in NSCLC patients. Materials and methods: A phase 11 trial was conducted to evaluate talabostat in combination with docetaxel in patients with advanced NSCLC after failure of previous platinum-based chemotherapy. In total, 42 patients were enrolled. Results: Talabostat was well tolerated. Two patients achieved a partial response and one achieved a complete response. Conclusion: There was no evidence that talabostat enhanced the clinical activity of docetaxel in patients with NSCLC. Eager, R. M. et al. (2009). Clinical Oncology 21, 464-472 (C) 2009 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
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