期刊
CLINICAL ONCOLOGY
卷 21, 期 6, 页码 448-450出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.clon.2009.01.006
关键词
BRCA1; breast cancer; chemotherapy; cisplatin; metastases
类别
资金
- German Cancer Aid (Deutsche Krebshilfe) [10 70 54]
Although BRCA1-associated breast carcinomas are frequently detected in nodal-negative stage, they typically present with an aggressive histopathological phenotype that is reflected by a poor prognosis and an increased risk for distant metastatic spread. Recent in vitro data suggest a high sensitivity of BRCA1-associated carcinomas to platinum-based chemotherapy and a lower sensitivity to anthracyclines and taxanes. This is explained by the key role of BRCA1 in DNA double-strand repair via homologous recombination, thereby leading to a higher sensitivity to DNA intercalating agents, such as platinum. Here we present the case of a woman suffering from BRCA1-associated metastatic breast carcinoma that was resistant to docetaxel, but responded strongly to cisplatin-containing chemotherapy. This supports the rationale of ongoing clinical studies. Rhiem, K. et at. (2009). Clinical Oncology 21, 448-450 (C) 2009 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
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