期刊
CLINICAL OBSTETRICS AND GYNECOLOGY
卷 56, 期 3, 页码 529-536出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/GRF.0b013e318299c39d
关键词
obesity; metabolic syndrome; appetite; adipogenesis; programming
资金
- National Institutes of Health [R01DK081756, R01HD054751]
A newly recognized primary cause of the obesity epidemic is the developmental programming effects of infants born to mothers with obesity or gestational diabetes, intrauterine growth-restricted newborns, and offspring exposed to environmental toxins including bisphenol A. The mechanisms which result in offspring obesity include the programming of the hypothalamic appetite pathway and adipogenic signals regulating lipogenesis. Processes include nutrient sensors, epigenetic modifications, and alterations in stem cell precursors of both appetite/satiety neurons and adipocytes which are modulated to potentiate offspring obesity. Future strategies for the prevention and therapy of obesity must address programming effects of the early life environment.
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